I experienced the exact same issue: open a file, and right after selecting an object the tool icons became unresponsive (but double-clicking a tool would still bring up the prefs), could not move an object with the mouse, drawing a shape resulted in a strange empty selection, ...
The menus would still work, though. Zooming in/out via the menus or minimizing the Inkscape windows to the task bar and maximizing it again would "awaken" Inkscape's GUI once more, but after one click on an icon or shape the whole thing would become unresponsive again.
System: dual screen, Nvidia 590, Windows 10.
It drove me insane - because it did not happen in the previous version.
However, I resolved it. Just before I installed .92, I had installed PangoBright to decrease the immense brightness levels of my Samsung SA850 screens, which was hurting my eyes. This tool covers the desktop with a darkening layer. As it turns out, it works with ALL applications I use (design apps and 3d apps) EXCEPT Inkscape! Scribus, PhotoLine, Blender, Adobe apps, Affinity apps, Unity, Godot, browsers, LibreOffice, Netbeans, Atom, etc. EVERYTHING works like a charm with PangoBright, but for InkScape.
When I turn off PangoBright for one screen, Inkscape works on that screen, but the GUI starts acting up on the other screen which is darkened by PangoBright.
Anyway, it is frustrating, because I generally work in a darker environment, and that means I will have to turn off PangoBright for the screen Inkscape is displaying on - which is painful to look at, and really unacceptable to my eyes for longer sessions.
I installed an alternative screen dimmer (desktop-dimmer https://github.com/sidneys/desktop-dimmer
), but alas, the same issue in Inkscape.
Again, it is ONLY Inkscape that has problems with a screen dimmer.
This leads me to believe that others here might have a similar tool running in the background - or perhaps other software that interferes with Inkscape's GUI.
By the way, tools like LightBulb do not interfere with Inkscape. https://github.com/Tyrrrz/LightBulb